Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

Jeroen J. A. Kampen (), David A. M. C. Vijver, Pieter L. A. Fraaij, Bart L. Haagmans, Mart M. Lamers, Nisreen Okba, Johannes P. C. Akker, Henrik Endeman, Diederik A. M. P. J. Gommers, Jan J. Cornelissen, Rogier A. S. Hoek, Menno M. Eerden, Dennis A. Hesselink, Herold J. Metselaar, Annelies Verbon, Jurriaan E. M. Steenwinkel, Georgina I. Aron, Eric C. M. Gorp, Sander Boheemen, Jolanda C. Voermans, Charles A. B. Boucher, Richard Molenkamp, Marion P. G. Koopmans, Corine Geurtsvankessel and Annemiek A. Eijk
Additional contact information
Jeroen J. A. Kampen: Erasmus MC
David A. M. C. Vijver: Erasmus MC
Pieter L. A. Fraaij: Erasmus MC
Bart L. Haagmans: Erasmus MC
Mart M. Lamers: Erasmus MC
Nisreen Okba: Erasmus MC
Johannes P. C. Akker: Erasmus MC
Henrik Endeman: Erasmus MC
Diederik A. M. P. J. Gommers: Erasmus MC
Jan J. Cornelissen: Erasmus MC
Rogier A. S. Hoek: Erasmus MC
Menno M. Eerden: Erasmus MC
Dennis A. Hesselink: Erasmus MC Transplant Institute
Herold J. Metselaar: Erasmus MC Transplant Institute
Annelies Verbon: Erasmus MC
Jurriaan E. M. Steenwinkel: Erasmus MC
Georgina I. Aron: Erasmus MC
Eric C. M. Gorp: Erasmus MC
Sander Boheemen: Erasmus MC
Jolanda C. Voermans: Erasmus MC
Charles A. B. Boucher: Erasmus MC
Richard Molenkamp: Erasmus MC
Marion P. G. Koopmans: Erasmus MC
Corine Geurtsvankessel: Erasmus MC
Annemiek A. Eijk: Erasmus MC

Nature Communications, 2021, vol. 12, issue 1, 1-6

Abstract: Abstract Key questions in COVID-19 are the duration and determinants of infectious virus shedding. Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 patients (17.8%) hospitalized with COVID-19. The median duration of shedding infectious virus is 8 days post onset of symptoms (IQR 5–11) and drops below 5% after 15.2 days post onset of symptoms (95% confidence interval (CI) 13.4–17.2). Multivariate analyses identify viral loads above 7 log10 RNA copies/mL (odds ratio [OR] of 14.7 (CI 3.57-58.1; p

Date: 2021
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DOI: 10.1038/s41467-020-20568-4

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