Genetic determinants of daytime napping and effects on cardiometabolic health

Hassan S. Dashti, Iyas Daghlas, Jacqueline M. Lane, Yunru Huang, Miriam S. Udler, Heming Wang, Hanna M. Ollila, Samuel E. Jones, Jaegil Kim, Andrew R. Wood, Michael N. Weedon, Stella Aslibekyan, Marta Garaulet () and Richa Saxena ()
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Hassan S. Dashti: Massachusetts General Hospital and Harvard Medical School
Iyas Daghlas: Massachusetts General Hospital and Harvard Medical School
Jacqueline M. Lane: Massachusetts General Hospital and Harvard Medical School
Yunru Huang: 23andMe, Inc.
Miriam S. Udler: Massachusetts General Hospital and Harvard Medical School
Heming Wang: Broad Institute
Hanna M. Ollila: Massachusetts General Hospital and Harvard Medical School
Samuel E. Jones: University of Helsinki
Jaegil Kim: GlaxoSmithKline
Andrew R. Wood: University of Exeter Medical School
Michael N. Weedon: University of Exeter Medical School
Stella Aslibekyan: 23andMe, Inc.
Marta Garaulet: Brigham and Women’s Hospital and Harvard Medical School
Richa Saxena: Massachusetts General Hospital and Harvard Medical School

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract Daytime napping is a common, heritable behavior, but its genetic basis and causal relationship with cardiometabolic health remain unclear. Here, we perform a genome-wide association study of self-reported daytime napping in the UK Biobank (n = 452,633) and identify 123 loci of which 61 replicate in the 23andMe research cohort (n = 541,333). Findings include missense variants in established drug targets for sleep disorders (HCRTR1, HCRTR2), genes with roles in arousal (TRPC6, PNOC), and genes suggesting an obesity-hypersomnolence pathway (PNOC, PATJ). Association signals are concordant with accelerometer-measured daytime inactivity duration and 33 loci colocalize with loci for other sleep phenotypes. Cluster analysis identifies three distinct clusters of nap-promoting mechanisms with heterogeneous associations with cardiometabolic outcomes. Mendelian randomization shows potential causal links between more frequent daytime napping and higher blood pressure and waist circumference.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20585-3

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DOI: 10.1038/s41467-020-20585-3

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