Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering
Mary Beth Wandel,
Craig A. Bell,
Jiayi Yu,
Maria C. Arno,
Nathan Z. Dreger,
Yen-Hao Hsu,
Anaïs Pitto-Barry,
Joshua C. Worch,
Andrew P. Dove () and
Matthew L. Becker ()
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Mary Beth Wandel: The University of Akron
Craig A. Bell: The University of Warwick
Jiayi Yu: The University of Akron
Maria C. Arno: The University of Birmingham
Nathan Z. Dreger: The University of Akron
Yen-Hao Hsu: The University of Akron
Anaïs Pitto-Barry: The University of Warwick
Joshua C. Worch: The University of Birmingham
Andrew P. Dove: The University of Birmingham
Matthew L. Becker: Duke University
Nature Communications, 2021, vol. 12, issue 1, 1-13
Abstract:
Abstract Complex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical, and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.
Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20610-5
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DOI: 10.1038/s41467-020-20610-5
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