Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

Nikos E. Papaioannou, Natallia Salei, Stephan Rambichler, Kaushikk Ravi, Jelena Popovic, Vanessa Küntzel, Christian H. K. Lehmann, Remi Fiancette, Johanna Salvermoser, Dominika W. Gajdasik, Ramona Mettler, Denise Messerer, Joana Carrelha, Caspar Ohnmacht, Dirk Haller, Ralf Stumm, Tobias Straub, Sten Eirik W. Jacobsen, Christian Schulz, David R. Withers, Gunnar Schotta, Diana Dudziak and Barbara U. Schraml ()
Additional contact information
Nikos E. Papaioannou: Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
Natallia Salei: Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
Stephan Rambichler: Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
Kaushikk Ravi: Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
Jelena Popovic: Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
Vanessa Küntzel: Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
Christian H. K. Lehmann: University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg
Remi Fiancette: Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
Johanna Salvermoser: Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
Dominika W. Gajdasik: Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
Ramona Mettler: Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
Denise Messerer: University Hospital Munich, LMU Munich
Joana Carrelha: University of Oxford
Caspar Ohnmacht: Helmholtz Center and Technical University of Munich
Dirk Haller: Technische Universität München
Ralf Stumm: Jena University Hospital
Tobias Straub: Core Facility Bioinformatics, Biomedical Center, LMU Munich
Sten Eirik W. Jacobsen: University of Oxford
Christian Schulz: University Hospital Munich, LMU Munich
David R. Withers: Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
Gunnar Schotta: LMU Munich
Diana Dudziak: University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg
Barbara U. Schraml: Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich

Nature Communications, 2021, vol. 12, issue 1, 1-20

Abstract: Abstract Conventional dendritic cells (cDC) are key activators of naive T cells, and can be targeted in adults to induce adaptive immunity, but in early life are considered under-developed or functionally immature. Here we show that, in early life, when the immune system develops, cDC2 exhibit a dual hematopoietic origin and, like other myeloid and lymphoid cells, develop in waves. Developmentally distinct cDC2 in early life, despite being distinguishable by fate mapping, are transcriptionally and functionally similar. cDC2 in early and adult life, however, are exposed to distinct cytokine environments that shape their transcriptional profile and alter their ability to sense pathogens, secrete cytokines and polarize T cells. We further show that cDC2 in early life, despite being distinct from cDC2 in adult life, are functionally competent and can induce T cell responses. Our results thus highlight the potential of harnessing cDC2 for boosting immunity in early life.

Date: 2021
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-20659-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20659-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-20659-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().