3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics

Hyogeun Shin, Sohyeon Jeong, Ju-Hyun Lee, Woong Sun, Nakwon Choi () and Il-Joo Cho ()
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Hyogeun Shin: Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)
Sohyeon Jeong: Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)
Ju-Hyun Lee: Korea University College of Medicine
Woong Sun: Korea University College of Medicine
Nakwon Choi: Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)
Il-Joo Cho: Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)

Nature Communications, 2021, vol. 12, issue 1, 1-18

Abstract: Abstract Investigation of neural circuit dynamics is crucial for deciphering the functional connections among regions of the brain and understanding the mechanism of brain dysfunction. Despite the advancements of neural circuit models in vitro, technologies for both precisely monitoring and modulating neural activities within three-dimensional (3D) neural circuit models have yet to be developed. Specifically, no existing 3D microelectrode arrays (MEAs) have integrated capabilities to stimulate surrounding neurons and to monitor the temporal evolution of the formation of a neural network in real time. Herein, we present a 3D high-density multifunctional MEA with optical stimulation and drug delivery for investigating neural circuit dynamics within engineered 3D neural tissues. We demonstrate precise measurements of synaptic latencies in 3D neural networks. We expect our 3D multifunctional MEA to open up opportunities for studies of neural circuits through precise, in vitro investigations of neural circuit dynamics with 3D brain models.

Date: 2021
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DOI: 10.1038/s41467-020-20763-3

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