Catalytic enantioselective C(sp3)–H functionalization involving radical intermediates

Chi Zhang, Zhong-Liang Li, Qiang-Shuai Gu () and Xin-Yuan Liu ()
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Chi Zhang: Southern University of Science and Technology
Zhong-Liang Li: Southern University of Science and Technology
Qiang-Shuai Gu: Southern University of Science and Technology
Xin-Yuan Liu: Southern University of Science and Technology

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract Recently, with the boosted development of radical chemistry, enantioselective functionalization of C(sp3)–H bonds via a radical pathway has witnessed a renaissance. In principle, two distinct catalytic modes, distinguished by the steps in which the stereochemistry is determined (the radical formation step or the radical functionalization step), can be devised. This Perspective discusses the state-of-the-art in the area of catalytic enantioselective C(sp3)–H functionalization involving radical intermediates as well as future challenges and opportunities.

Date: 2021
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DOI: 10.1038/s41467-020-20770-4

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