STIM-Orai1 signaling regulates fluidity of cytoplasm during membrane blebbing

Kana Aoki, Shota Harada, Keita Kawaji, Kenji Matsuzawa, Seiichi Uchida and Junichi Ikenouchi ()
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Kana Aoki: Kyushu University
Shota Harada: Kyushu University
Keita Kawaji: Kyushu University
Kenji Matsuzawa: Kyushu University
Seiichi Uchida: Kyushu University
Junichi Ikenouchi: Kyushu University

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract The cytoplasm in mammalian cells is considered homogeneous. In this study, we report that the cytoplasmic fluidity is regulated in the blebbing cells; the cytoplasm of rapidly expanding membrane blebs is more disordered than the cytoplasm of retracting blebs. The increase of cytoplasmic fluidity in the expanding bleb is caused by a sharp rise in the calcium concentration. The STIM-Orai1 pathway regulates this rapid and restricted increase of calcium in the expanding blebs. Conversely, activated ERM protein binds to Orai1 to inhibit the store-operated calcium entry in retracting blebs, which results in decreased in cytoplasmic calcium, rapid reassembly of the actin cortex.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20826-5

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DOI: 10.1038/s41467-020-20826-5

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