A hybrid semiconducting organosilica-based O2 nanoeconomizer for on-demand synergistic photothermally boosted radiotherapy

Wei Tang, Zhen Yang (), Liangcan He, Liming Deng, Parinaz Fathi, Shoujun Zhu, Ling Li, Bo Shen, Zhantong Wang, Orit Jacobson, Jibin Song, Jianhua Zou, Ping Hu, Min Wang, Jing Mu, Yaya Cheng, Yuanyuan Ma, Longguang Tang, Wenpei Fan () and Xiaoyuan Chen ()
Additional contact information
Wei Tang: National Institutes of Health
Zhen Yang: National Institutes of Health
Liangcan He: National Institutes of Health
Liming Deng: National Institutes of Health
Parinaz Fathi: National Institutes of Health
Shoujun Zhu: Jilin University
Ling Li: National Institutes of Health
Bo Shen: Fudan University
Zhantong Wang: National Institutes of Health
Orit Jacobson: National Institutes of Health
Jibin Song: Fuzhou University
Jianhua Zou: National Institutes of Health
Ping Hu: Chinese Academy of Sciences
Min Wang: Chinese Academy of Sciences
Jing Mu: National Institutes of Health
Yaya Cheng: National Institutes of Health
Yuanyuan Ma: National Institutes of Health
Longguang Tang: National Institutes of Health
Wenpei Fan: China Pharmaceutical University
Xiaoyuan Chen: National University of Singapore

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract The outcome of radiotherapy is significantly restricted by tumor hypoxia. To overcome this obstacle, one prevalent solution is to increase intratumoral oxygen supply. However, its effectiveness is often limited by the high metabolic demand for O2 by cancer cells. Herein, we develop a hybrid semiconducting organosilica-based O2 nanoeconomizer pHPFON-NO/O2 to combat tumor hypoxia. Our solution is twofold: first, the pHPFON-NO/O2 interacts with the acidic tumor microenvironment to release NO for endogenous O2 conservation; second, it releases O2 in response to mild photothermal effect to enable exogenous O2 infusion. Additionally, the photothermal effect can be increased to eradicate tumor residues with radioresistant properties due to other factors. This “reducing expenditure of O2 and broadening sources” strategy significantly alleviates tumor hypoxia in multiple ways, greatly enhances the efficacy of radiotherapy both in vitro and in vivo, and demonstrates the synergy between on-demand temperature-controlled photothermal and oxygen-elevated radiotherapy for complete tumor response.

Date: 2021
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DOI: 10.1038/s41467-020-20860-3

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