NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines

Yuli He, Huayue Song, Jian Chen and Shaolin Zhu ()
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Yuli He: Nanjing University
Huayue Song: Nanjing University
Jian Chen: Nanjing University
Shaolin Zhu: Nanjing University

Nature Communications, 2021, vol. 12, issue 1, 1-7

Abstract: Abstract Enantiomerically pure chiral amines and related amide derivatives are privilege motifs in many pharmacologically active molecules. In comparison to the well-established hydroamination, the transition metal-catalysed asymmetric hydrofunctionalization of enamines provides a complementary approach for their construction. Here we report a NiH-catalysed enantio- and regioselective reductive hydroarylation of N-acyl enamines, allowing for the practical access to a broad range of structurally diverse, enantioenriched benzylamines under mild, operationally simple reaction conditions.

Date: 2021
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DOI: 10.1038/s41467-020-20888-5

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