Uncovering de novo gene birth in yeast using deep transcriptomics

William R. Blevins, Jorge Ruiz-Orera, Xavier Messeguer, Bernat Blasco-Moreno, José Luis Villanueva-Cañas, Lorena Espinar, Juana Díez, Lucas B. Carey and M. Mar Albà ()
Additional contact information
William R. Blevins: Hospital del Mar Research Institute (IMIM) and Universitat Pompeu Fabra (UPF)
Jorge Ruiz-Orera: Hospital del Mar Research Institute (IMIM) and Universitat Pompeu Fabra (UPF)
Xavier Messeguer: Universitat Politècnica de Catalunya (UPC)
Bernat Blasco-Moreno: Universitat Pompeu Fabra (UPF)
José Luis Villanueva-Cañas: Hospital del Mar Research Institute (IMIM) and Universitat Pompeu Fabra (UPF)
Lorena Espinar: Universitat Pompeu Fabra (UPF)
Juana Díez: Universitat Pompeu Fabra (UPF)
Lucas B. Carey: Universitat Pompeu Fabra (UPF)
M. Mar Albà: Hospital del Mar Research Institute (IMIM) and Universitat Pompeu Fabra (UPF)

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract De novo gene origination has been recently established as an important mechanism for the formation of new genes. In organisms with a large genome, intergenic and intronic regions provide plenty of raw material for new transcriptional events to occur, but little is know about how de novo transcripts originate in more densely-packed genomes. Here, we identify 213 de novo originated transcripts in Saccharomyces cerevisiae using deep transcriptomics and genomic synteny information from multiple yeast species grown in two different conditions. We find that about half of the de novo transcripts are expressed from regions which already harbor other genes in the opposite orientation; these transcripts show similar expression changes in response to stress as their overlapping counterparts, and some appear to translate small proteins. Thus, a large fraction of de novo genes in yeast are likely to co-evolve with already existing genes.

Date: 2021
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/s41467-021-20911-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-20911-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-20911-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().