Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2

Jack Rhodes, Huanjie Yang, Steven Moussu, Freddy Boutrot, Julia Santiago and Cyril Zipfel ()
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Jack Rhodes: University of East Anglia, Norwich Research Park
Huanjie Yang: University of Zurich
Steven Moussu: University of Lausanne
Freddy Boutrot: University of East Anglia, Norwich Research Park
Julia Santiago: University of Lausanne
Cyril Zipfel: University of East Anglia, Norwich Research Park

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract Plant genomes encode hundreds of receptor kinases and peptides, but the number of known plant receptor-ligand pairs is limited. We report that the Arabidopsis leucine-rich repeat receptor kinase LRR-RK MALE DISCOVERER 1-INTERACTING RECEPTOR LIKE KINASE 2 (MIK2) is the receptor for the SERINE RICH ENDOGENOUS PEPTIDE (SCOOP) phytocytokines. MIK2 is necessary and sufficient for immune responses triggered by multiple SCOOP peptides, suggesting that MIK2 is the receptor for this divergent family of peptides. Accordingly, the SCOOP12 peptide directly binds MIK2 and triggers complex formation between MIK2 and the BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) co-receptor. MIK2 is required for resistance to the important root pathogen Fusarium oxysporum. Notably, we reveal that Fusarium proteomes encode SCOOP-like sequences, and corresponding synthetic peptides induce MIK2-dependent immune responses. These results suggest that MIK2 may recognise Fusarium-derived SCOOP-like sequences to induce immunity against Fusarium. The definition of SCOOPs as MIK2 ligands will help to unravel the multiple roles played by MIK2 during plant growth, development and stress responses.

Date: 2021
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DOI: 10.1038/s41467-021-20932-y

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