Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action

Feng Gao, Tianyi Shao, Yunpeng Yu, Yujie Xiong () and Lihua Yang ()
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Feng Gao: Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China
Tianyi Shao: Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China
Yunpeng Yu: Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China
Yujie Xiong: Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China
Lihua Yang: Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China

Nature Communications, 2021, vol. 12, issue 1, 1-18

Abstract: Abstract Acting by producing reactive oxygen species (ROS) in situ, nanozymes are promising as antimicrobials. ROS’ intrinsic inability to distinguish bacteria from mammalian cells, however, deprives nanozymes of the selectivity necessary for an ideal antimicrobial. Here we report that nanozymes that generate surface-bound ROS selectively kill bacteria over mammalian cells. This result is robust across three distinct nanozymes that universally generate surface-bound ROS, with an oxidase-like silver-palladium bimetallic alloy nanocage, AgPd0.38, being the lead model. The selectivity is attributable to both the surface-bound nature of ROS these nanozymes generate and an unexpected antidote role of endocytosis. Though surface-bound, the ROS on AgPd0.38 efficiently eliminated antibiotic-resistant bacteria and effectively delayed the onset of bacterial resistance emergence. When used as coating additives, AgPd0.38 enabled an inert substrate to inhibit biofilm formation and suppress infection-related immune responses in mouse models. This work opens an avenue toward biocompatible nanozymes and may have implication in our fight against antimicrobial resistance.

Date: 2021
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DOI: 10.1038/s41467-021-20965-3

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