The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis

Ivo S. Muskens, Shaobo Li, Thomas Jackson, Natalina Elliot, Helen M. Hansen, Swe Swe Myint, Priyatama Pandey, Jeremy M. Schraw, Ritu Roy, Joaquin Anguiano, Katerina Goudevenou, Kimberly D. Siegmund, Philip J. Lupo, Marella F. T. R. de Bruijn, Kyle M. Walsh, Paresh Vyas, Xiaomei Ma, Anindita Roy, Irene Roberts, Joseph L. Wiemels and Adam J. de Smith ()
Additional contact information
Ivo S. Muskens: Keck School of Medicine of the University of Southern California
Shaobo Li: Keck School of Medicine of the University of Southern California
Thomas Jackson: NIHR Oxford Biomedical Centre
Natalina Elliot: NIHR Oxford Biomedical Centre
Helen M. Hansen: University of California San Francisco
Swe Swe Myint: Keck School of Medicine of the University of Southern California
Priyatama Pandey: Keck School of Medicine of the University of Southern California
Jeremy M. Schraw: Baylor College of Medicine
Ritu Roy: University of California San Francisco
Joaquin Anguiano: University of California San Francisco
Katerina Goudevenou: NIHR Oxford Biomedical Centre
Kimberly D. Siegmund: Keck School of Medicine of the University of Southern California
Philip J. Lupo: Baylor College of Medicine
Marella F. T. R. de Bruijn: University of Oxford
Kyle M. Walsh: Duke University
Paresh Vyas: University of Oxford
Xiaomei Ma: Yale School of Public Health
Anindita Roy: NIHR Oxford Biomedical Centre
Irene Roberts: NIHR Oxford Biomedical Centre
Joseph L. Wiemels: Keck School of Medicine of the University of Southern California
Adam J. de Smith: Keck School of Medicine of the University of Southern California

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract Down syndrome is associated with genome-wide perturbation of gene expression, which may be mediated by epigenetic changes. We perform an epigenome-wide association study on neonatal bloodspots comparing 196 newborns with Down syndrome and 439 newborns without Down syndrome, adjusting for cell-type heterogeneity, which identifies 652 epigenome-wide significant CpGs (P

Date: 2021
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DOI: 10.1038/s41467-021-21064-z

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