Ph2 encodes the mismatch repair protein MSH7-3D that inhibits wheat homoeologous recombination

Heïdi Serra (), Radim Svačina, Ute Baumann, Ryan Whitford, Tim Sutton, Jan Bartoš and Pierre Sourdille ()
Additional contact information
Heïdi Serra: Université Clermont Auvergne
Radim Svačina: Centre of the Region Hana for Biotechnological and Agricultural Research
Ute Baumann: University of Adelaide, Waite Campus, PMB1
Ryan Whitford: University of Adelaide, Waite Campus, PMB1
Tim Sutton: University of Adelaide, Waite Campus, PMB1
Jan Bartoš: Centre of the Region Hana for Biotechnological and Agricultural Research
Pierre Sourdille: Université Clermont Auvergne

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract Meiotic recombination is a critical process for plant breeding, as it creates novel allele combinations that can be exploited for crop improvement. In wheat, a complex allohexaploid that has a diploid-like behaviour, meiotic recombination between homoeologous or alien chromosomes is suppressed through the action of several loci. Here, we report positional cloning of Pairing homoeologous 2 (Ph2) and functional validation of the wheat DNA mismatch repair protein MSH7-3D as a key inhibitor of homoeologous recombination, thus solving a half-century-old question. Similar to ph2 mutant phenotype, we show that mutating MSH7-3D induces a substantial increase in homoeologous recombination (up to 5.5 fold) in wheat-wild relative hybrids, which is also associated with a reduction in homologous recombination. These data reveal a role for MSH7-3D in meiotic stabilisation of allopolyploidy and provides an opportunity to improve wheat’s genetic diversity through alien gene introgression, a major bottleneck facing crop improvement.

Date: 2021
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-21127-1 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21127-1

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-21127-1

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().