Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice

Haohao Wu, Charles Petitpré, Paula Fontanet, Anil Sharma, Carmelo Bellardita, Rolen M. Quadros, Paulo R. Jannig, Yiqiao Wang, J. Alexander Heimel, Kylie K. Y. Cheung, Simone Wanderoy, Yang Xuan, Konstantinos Meletis, Jorge Ruas, Channabasavaiah B. Gurumurthy, Ole Kiehn, Saida Hadjab and François Lallemend ()
Additional contact information
Haohao Wu: Karolinska Institutet
Charles Petitpré: Karolinska Institutet
Paula Fontanet: Karolinska Institutet
Anil Sharma: Karolinska Institutet
Carmelo Bellardita: Karolinska Institutet
Rolen M. Quadros: University of Nebraska Medical Center
Paulo R. Jannig: Karolinska Institutet
Yiqiao Wang: Karolinska Institutet
J. Alexander Heimel: Netherlands Institute for Neuroscience
Kylie K. Y. Cheung: Karolinska Institutet
Simone Wanderoy: Karolinska Institutet
Yang Xuan: Karolinska Institutet
Konstantinos Meletis: Karolinska Institutet
Jorge Ruas: Karolinska Institutet
Channabasavaiah B. Gurumurthy: University of Nebraska Medical Center
Ole Kiehn: Karolinska Institutet
Saida Hadjab: Karolinska Institutet
François Lallemend: Karolinska Institutet

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Proprioceptive neurons (PNs) are essential for the proper execution of all our movements by providing muscle sensory feedback to the central motor network. Here, using deep single cell RNAseq of adult PNs coupled with virus and genetic tracings, we molecularly identify three main types of PNs (Ia, Ib and II) and find that they segregate into eight distinct subgroups. Our data unveil a highly sophisticated organization of PNs into discrete sensory input channels with distinct spatial distribution, innervation patterns and molecular profiles. Altogether, these features contribute to finely regulate proprioception during complex motor behavior. Moreover, while Ib- and II-PN subtypes are specified around birth, Ia-PN subtypes diversify later in life along with increased motor activity. We also show Ia-PNs plasticity following exercise training, suggesting Ia-PNs are important players in adaptive proprioceptive function in adult mice.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21173-9

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DOI: 10.1038/s41467-021-21173-9

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