Methodological quality of COVID-19 clinical research

Richard G. Jung, Pietro Di Santo, Cole Clifford, Graeme Prosperi-Porta, Stephanie Skanes, Annie Hung, Simon Parlow, Sarah Visintini, F. Daniel Ramirez, Trevor Simard and Benjamin Hibbert ()
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Richard G. Jung: University of Ottawa Heart Institute
Pietro Di Santo: University of Ottawa Heart Institute
Cole Clifford: University of Ottawa
Graeme Prosperi-Porta: Cumming School of Medicine
Stephanie Skanes: University of Ottawa
Annie Hung: The Ottawa Hospital
Simon Parlow: University of Ottawa Heart Institute
Sarah Visintini: University of Ottawa Heart Institute
F. Daniel Ramirez: University of Ottawa Heart Institute
Trevor Simard: University of Ottawa Heart Institute
Benjamin Hibbert: University of Ottawa Heart Institute

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract The COVID-19 pandemic began in early 2020 with major health consequences. While a need to disseminate information to the medical community and general public was paramount, concerns have been raised regarding the scientific rigor in published reports. We performed a systematic review to evaluate the methodological quality of currently available COVID-19 studies compared to historical controls. A total of 9895 titles and abstracts were screened and 686 COVID-19 articles were included in the final analysis. Comparative analysis of COVID-19 to historical articles reveals a shorter time to acceptance (13.0[IQR, 5.0–25.0] days vs. 110.0[IQR, 71.0–156.0] days in COVID-19 and control articles, respectively; p

Date: 2021
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DOI: 10.1038/s41467-021-21220-5

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