Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes

Adam B. Weiner, Thiago Vidotto, Yang Liu, Adrianna A. Mendes, Daniela C. Salles, Farzana A. Faisal, Sanjana Murali, Matthew McFarlane, Eddie L. Imada, Xin Zhao, Ziwen Li, Elai Davicioni, Luigi Marchionni, Arul M. Chinnaiyan, Stephen J. Freedland, Daniel E. Spratt, Jennifer D. Wu, Tamara L. Lotan and Edward M. Schaeffer ()
Additional contact information
Adam B. Weiner: Northwestern University Feinberg School of Medicine
Thiago Vidotto: Johns Hopkins University School of Medicine
Yang Liu: Decipher Biosciences
Adrianna A. Mendes: Johns Hopkins University School of Medicine
Daniela C. Salles: Johns Hopkins University School of Medicine
Farzana A. Faisal: Johns Hopkins University School of Medicine
Sanjana Murali: Johns Hopkins University School of Medicine
Matthew McFarlane: University of Michigan
Eddie L. Imada: Johns Hopkins University School of Medicine
Xin Zhao: Decipher Biosciences
Ziwen Li: Decipher Biosciences
Elai Davicioni: Decipher Biosciences
Luigi Marchionni: Johns Hopkins University School of Medicine
Arul M. Chinnaiyan: University of Michigan
Stephen J. Freedland: Cedars-Sinai Medical Center
Daniel E. Spratt: University of Michigan
Jennifer D. Wu: Northwestern University Feinberg School of Medicine
Tamara L. Lotan: Johns Hopkins University School of Medicine
Edward M. Schaeffer: Northwestern University Feinberg School of Medicine

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract Black men die more often of prostate cancer yet, interestingly, may derive greater survival benefits from immune-based treatment with sipuleucel-T. Since no signatures of immune-responsiveness exist for prostate cancer, we explored race-based immune-profiles to identify vulnerabilities. Here we show in multiple independent cohorts comprised of over 1,300 patient samples annotated with either self-identified race or genetic ancestry, prostate tumors from Black men or men of African ancestry have increases in plasma cell infiltrate and augmented markers of NK cell activity and IgG expression. These findings are associated with improved recurrence-free survival following surgery and nominate plasma cells as drivers of prostate cancer immune-responsiveness.

Date: 2021
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DOI: 10.1038/s41467-021-21245-w

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