Travelling spindles create necessary conditions for spike-timing-dependent plasticity in humans

Charles W. Dickey (), Anna Sargsyan, Joseph R. Madsen, Emad N. Eskandar, Sydney S. Cash and Eric Halgren ()
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Charles W. Dickey: University of California, San Diego
Anna Sargsyan: University of California, San Diego
Joseph R. Madsen: Boston Children’s Hospital, Harvard Medical School
Emad N. Eskandar: Montefiore Medical Center, Albert Einstein College of Medicine
Sydney S. Cash: Harvard Medical School
Eric Halgren: University of California, San Diego

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract Sleep spindles facilitate memory consolidation in the cortex during mammalian non-rapid eye movement sleep. In rodents, phase-locked firing during spindles may facilitate spike-timing-dependent plasticity by grouping pre-then-post-synaptic cell firing within ~25 ms. Currently, microphysiological evidence in humans for conditions conducive for spike-timing-dependent plasticity during spindles is absent. Here, we analyze field potentials and unit firing from middle/upper layers during spindles from 10 × 10 microelectrode arrays at 400 μm pitch in humans. We report strong tonic and phase-locked increases in firing and co-firing within 25 ms during spindles, especially those co-occurring with down-to-upstate transitions. Co-firing, spindle co-occurrence, and spindle coherence are greatest within ~2 mm, and high co-firing of units on different contacts depends on high spindle coherence between those contacts. Spindles propagate at ~0.28 m/s in distinct patterns, with correlated cell co-firing sequences. Spindles hence organize spatiotemporal patterns of neuronal co-firing in ways that may provide pre-conditions for plasticity during non-rapid eye movement sleep.

Date: 2021
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DOI: 10.1038/s41467-021-21298-x

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