The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome

Camille Bourgneuf, Danielle Bailbé, Antonin Lamazière, Charlotte Dupont, Marthe Moldes, Dominique Farabos, Natacha Roblot, Camille Gauthier, Emmanuelle Mathieu d’Argent, Joelle Cohen-Tannoudji, Danielle Monniaux, Bruno Fève, Jamileh Movassat, Nathalie di Clemente and Chrystèle Racine ()
Additional contact information
Camille Bourgneuf: Centre de Recherche Saint-Antoine (CRSA)
Danielle Bailbé: UMR 8251, CNRS, F-75013
Antonin Lamazière: Centre de Recherche Saint-Antoine (CRSA)
Charlotte Dupont: Centre de Recherche Saint-Antoine (CRSA)
Marthe Moldes: Centre de Recherche Saint-Antoine (CRSA)
Dominique Farabos: Centre de Recherche Saint-Antoine (CRSA)
Natacha Roblot: Centre de Recherche Saint-Antoine (CRSA)
Camille Gauthier: Centre de Recherche Saint-Antoine (CRSA)
Emmanuelle Mathieu d’Argent: Centre de Recherche Saint-Antoine (CRSA)
Joelle Cohen-Tannoudji: UMR 8251, CNRS, F-75013
Danielle Monniaux: IFCE
Bruno Fève: Centre de Recherche Saint-Antoine (CRSA)
Jamileh Movassat: UMR 8251, CNRS, F-75013
Nathalie di Clemente: Centre de Recherche Saint-Antoine (CRSA)
Chrystèle Racine: Centre de Recherche Saint-Antoine (CRSA)

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract Polycystic ovary syndrome (PCOS) is characterized by an oligo-anovulation, hyperandrogenism and polycystic ovarian morphology combined with major metabolic disturbances. However, despite the high prevalence and the human and economic consequences of this syndrome, its etiology remains unknown. In this study, we show that female Goto-Kakizaki (GK) rats, a type 2 diabetes mellitus model, encapsulate naturally all the reproductive and metabolic hallmarks of lean women with PCOS at puberty and in adulthood. The analysis of their gestation and of their fetuses demonstrates that this PCOS-like phenotype is developmentally programmed. GK rats also develop features of ovarian hyperstimulation syndrome. Lastly, a comparison between GK rats and a cohort of women with PCOS reveals a similar reproductive signature. Thus, this spontaneous rodent model of PCOS represents an original tool for the identification of the mechanisms involved in its pathogenesis and for the development of novel strategies for its treatment.

Date: 2021
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DOI: 10.1038/s41467-021-21308-y

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