Notch2-mediated plasticity between marginal zone and follicular B cells

Markus Lechner, Thomas Engleitner, Tea Babushku, Marc Schmidt-Supprian, Roland Rad, Lothar J. Strobl and Ursula Zimber-Strobl ()
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Markus Lechner: German Research Center for Environmental Health
Thomas Engleitner: Technical University of Munich
Tea Babushku: German Research Center for Environmental Health
Marc Schmidt-Supprian: Technical University of Munich
Roland Rad: Technical University of Munich
Lothar J. Strobl: German Research Center for Environmental Health
Ursula Zimber-Strobl: German Research Center for Environmental Health

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Follicular B (FoB) and marginal zone B (MZB) cells are functionally and spatially distinct mature B cell populations in the spleen, originating from a Notch2-dependent fate decision after splenic influx of immature transitional B cells. In the B cell follicle, a Notch2-signal is provided by DLL-1-expressing fibroblasts. However, it is unclear whether FoB cells, which are in close contact with these DLL-1 expressing fibroblasts, can also differentiate to MZB cells if they receive a Notch2-signal. Here, we show induced Notch2IC-expression in FoB cells re-programs mature FoB cells into bona fide MZB cells as is evident from the surface phenotype, localization, immunological function and transcriptome of these cells. Furthermore, the lineage conversion from FoB to MZB cells occurs in immunocompetent wildtype mice. These findings demonstrate plasticity between mature FoB and MZB cells that can be driven by a singular signaling event, the activation of Notch2.

Date: 2021
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DOI: 10.1038/s41467-021-21359-1

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