SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

Nicolas Huot, Philippe Rascle, Caroline Petitdemange, Vanessa Contreras, Christina M. Stürzel, Eduard Baquero, Justin L. Harper, Caroline Passaes, Rachel Legendre, Hugo Varet, Yoann Madec, Ulrike Sauermann, Christiane Stahl-Hennig, Jacob Nattermann, Asier Saez-Cirion, Roger Grand, R. Keith Reeves, Mirko Paiardini, Frank Kirchhoff, Beatrice Jacquelin and Michaela Müller-Trutwin ()
Additional contact information
Nicolas Huot: Unité HIV, Inflammation et Persistance
Philippe Rascle: Unité HIV, Inflammation et Persistance
Caroline Petitdemange: Unité HIV, Inflammation et Persistance
Vanessa Contreras: IDMIT Department, IBFJ
Christina M. Stürzel: Ulm University Medical Center
Eduard Baquero: Unité de Virologie Structurale
Justin L. Harper: Emory University
Caroline Passaes: Unité HIV, Inflammation et Persistance
Rachel Legendre: Institut Pasteur
Hugo Varet: Institut Pasteur
Yoann Madec: Institut Pasteur; Epidemiology of Emerging Diseases Unit
Ulrike Sauermann: Deutsches Primatenzentrum - Leibniz Institut für Primatenforschung
Christiane Stahl-Hennig: Deutsches Primatenzentrum - Leibniz Institut für Primatenforschung
Jacob Nattermann: Universitätsklinikum Bonn, Germany; German Center for Infection Research (DZIF)
Asier Saez-Cirion: Unité HIV, Inflammation et Persistance
Roger Grand: IDMIT Department, IBFJ
R. Keith Reeves: Harvard Medical School
Mirko Paiardini: Emory University
Frank Kirchhoff: Ulm University Medical Center
Beatrice Jacquelin: Unité HIV, Inflammation et Persistance
Michaela Müller-Trutwin: Unité HIV, Inflammation et Persistance

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of SIVagm infection in secondary lymphoid tissues. We demonstrate that SIVagm infection induces the expansion of terminally differentiated NKG2alow NK cells in secondary lymphoid organs displaying an adaptive transcriptional profile and increased MHC-E-restricted cytotoxicity in response to SIV Env peptides while expressing little IFN-γ. Such NK cell differentiation was lacking in SIVmac-infected macaques. Adaptive NK cells displayed no increased NKG2C expression. This study reveals a previously unknown profile of NK cell adaptation to a viral infection, thus accelerating strategies toward NK-cell directed therapies and viral control in tissues.

Date: 2021
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-021-21402-1 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21402-1

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-21402-1

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().