Degradable polymeric vehicles for postoperative pain management

Natasha C. Brigham, Ru-Rong Ji and Matthew L. Becker ()
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Natasha C. Brigham: Duke University
Ru-Rong Ji: Duke University
Matthew L. Becker: Duke University

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Effective control of pain management has the potential to significantly decrease the need for prescription opioids following a surgical procedure. While extended release products for pain management are available commercially, the implementation of a device that safely and reliably provides extended analgesia and is sufficiently flexible to facilitate a diverse array of release profiles would serve to advance patient comfort, quality of care and compliance following surgical procedures. Herein, we review current polymeric systems that could be utilized in new, controlled post-operative pain management devices and highlight where opportunities for improvement exist.

Date: 2021
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DOI: 10.1038/s41467-021-21438-3

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