Data linkage to evaluate the long-term risk of HIV infection in individuals seeking post-exposure prophylaxis

Frédérique Hovaguimian (), Huldrych F. Günthard, Christoph Hauser, Anna Conen, Enos Bernasconi, Alexandra Calmy, Matthias Cavassini, Marco Seneghini, Alex Marzel, Henriette Heinrich, Alexandra Scherrer, Julien Riou, Adrian Spoerri, Kurt Schmidlin, Suraj Balakrishna, Dominique L. Braun, Silvana K. Rampini, Jan S. Fehr and Roger D. Kouyos
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Frédérique Hovaguimian: University Hospital of Zurich
Huldrych F. Günthard: University Hospital of Zurich
Christoph Hauser: Bern University Hospital, University of Bern
Anna Conen: Kantonsspital Aarau
Enos Bernasconi: Regional Hospital Lugano
Alexandra Calmy: Geneva University Hospital
Matthias Cavassini: Lausanne University Hospital
Marco Seneghini: Division of Infectious Diseases and Hospital Epidemiology, Kantonsspital St. Gallen
Alex Marzel: Schulthess Clinic
Henriette Heinrich: University Hospital of Zurich
Alexandra Scherrer: University Hospital of Zurich
Julien Riou: University of Bern
Adrian Spoerri: University of Bern
Kurt Schmidlin: University of Bern
Suraj Balakrishna: University Hospital of Zurich
Dominique L. Braun: University Hospital of Zurich
Silvana K. Rampini: University Hospital of Zurich, University of Zurich
Jan S. Fehr: University Hospital of Zurich
Roger D. Kouyos: University Hospital of Zurich

Nature Communications, 2021, vol. 12, issue 1, 1-8

Abstract: Abstract Evidence on the long-term risk of HIV infection in individuals taking HIV post-exposure prophylaxis remains limited. In this retrospective data linkage study, we evaluate the occurrence of HIV infection in 975 individuals who sought post-exposure prophylaxis in a tertiary hospital between 2007 and 2013. Using privacy preserving probabilistic linkage, we link these 975 records with two observational databases providing data on HIV events (Zurich Primary HIV Infection study and the Swiss HIV Cohort Study). This enables us to identify 22 HIV infections and to obtain long-term follow-up data, which reveal a median of 4.1 years between consultation for post-exposure prophylaxis and HIV diagnosis. Even though men who have sex with men constitute only 35.8% of those seeking post-exposure prophylaxis, all 22 events occur in this subgroup. These findings should strongly encourage early consideration of pre-exposure prophylaxis in men who have sex with men after a first episode of post-exposure prophylaxis.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21485-w

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DOI: 10.1038/s41467-021-21485-w

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