The prevalence of antibodies to SARS-CoV-2 among blood donors in China

Le Chang, Wangheng Hou, Lei Zhao, Yali Zhang, Yanbin Wang, Linfeng Wu, Tingting Xu, Lilin Wang, Juan Wang, Jian Ma, Lan Wang, Junpeng Zhao, Jing Xu, Juan Dong, Ying Yan, Ru Yang, Yu Li, Fei Guo, Wenjuan Cheng, Yingying Su, Jinfeng Zeng, Wei Han, Tong Cheng, Jun Zhang, Quan Yuan (), Ningshao Xia and Lunan Wang ()
Additional contact information
Le Chang: Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences
Wangheng Hou: Xiamen University
Lei Zhao: Wuhan Blood Center
Yali Zhang: Xiamen University
Yanbin Wang: Hebei Province Blood Center
Linfeng Wu: Shenzhen Blood Center
Tingting Xu: Wuhan Blood Center
Lilin Wang: Shenzhen Blood Center
Juan Wang: Xiamen University
Jian Ma: Xiamen University
Lan Wang: Wuhan Blood Center
Junpeng Zhao: Shenzhen Blood Center
Jing Xu: Wuhan Blood Center
Juan Dong: Wuhan Blood Center
Ying Yan: Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences
Ru Yang: Wuhan Blood Center
Yu Li: Wuhan Blood Center
Fei Guo: Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences
Wenjuan Cheng: Wuhan Blood Center
Yingying Su: Xiamen University
Jinfeng Zeng: Shenzhen Blood Center
Wei Han: Hebei Province Blood Center
Tong Cheng: Xiamen University
Jun Zhang: Xiamen University
Quan Yuan: Xiamen University
Ningshao Xia: Xiamen University
Lunan Wang: Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract In this study, we investigate the seroprevalence of SARS-CoV-2 antibodies among blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang in China. From January to April 2020, 38,144 healthy blood donors in the three cities were tested for total antibody against SARS-CoV-2 followed by pseudotype SARS-CoV-2 neutralization tests, IgG, and IgM antibody testing. Finally, a total of 398 donors were confirmed positive. The age- and sex-standardized SARS-CoV-2 seroprevalence among 18–60 year-old adults (18–65 year-old in Shenzhen) was 2.66% (95% CI: 2.24%–3.07%) in Wuhan, 0.033% (95% CI: 0.0029%–0.267%) in Shenzhen, and 0.0028% (95% CI: 0.0001%–0.158%) in Shijiazhuang, respectively. Female sex and older-age were identified to be independent risk factors for SARS-CoV-2 seropositivity among blood donors in Wuhan. As most of the population of China remained uninfected during the early wave of the COVID-19 pandemic, effective public health measures are still certainly required to block viral spread before a vaccine is widely available.

Date: 2021
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DOI: 10.1038/s41467-021-21503-x

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