Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure

Mallory Paynich Murray, Isaac Engel, Grégory Seumois, Sara Herrera- De la Mata, Sandy Lucette Rosales, Ashu Sethi, Ashmitaa Logandha Ramamoorthy Premlal, Goo-Young Seo, Jason Greenbaum, Pandurangan Vijayanand, James P. Scott-Browne () and Mitchell Kronenberg ()
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Mallory Paynich Murray: La Jolla Institute for Immunology
Isaac Engel: La Jolla Institute for Immunology
Grégory Seumois: La Jolla Institute for Immunology
Sara Herrera- De la Mata: La Jolla Institute for Immunology
Sandy Lucette Rosales: La Jolla Institute for Immunology
Ashu Sethi: La Jolla Institute for Immunology
Ashmitaa Logandha Ramamoorthy Premlal: La Jolla Institute for Immunology
Goo-Young Seo: La Jolla Institute for Immunology
Jason Greenbaum: La Jolla Institute for Immunology
Pandurangan Vijayanand: La Jolla Institute for Immunology
James P. Scott-Browne: La Jolla Institute for Immunology
Mitchell Kronenberg: La Jolla Institute for Immunology

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract Invariant natural killer T cells (iNKT cells) differentiate into thymic and peripheral NKT1, NKT2 and NKT17 subsets. Here we use RNA-seq and ATAC-seq analyses and show iNKT subsets are similar, regardless of tissue location. Lung iNKT cell subsets possess the most distinct location-specific features, shared with other innate lymphocytes in the lung, possibly consistent with increased activation. Following antigenic stimulation, iNKT cells undergo chromatin and transcriptional changes delineating two populations: one similar to follicular helper T cells and the other NK or effector like. Phenotypic analysis indicates these changes are observed long-term, suggesting that iNKT cells gene programs are not fixed, but they are capable of chromatin remodeling after antigen to give rise to additional subsets.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21574-w

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DOI: 10.1038/s41467-021-21574-w

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