Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core

Haiyan Zhao, Natalie Young, Jens Kalchschmidt, Jenna Lieberman, Laila El Khattabi, Rafael Casellas and Francisco J. Asturias ()
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Haiyan Zhao: University of Colorado Anschutz Medical School
Natalie Young: University of Colorado Anschutz Medical School
Jens Kalchschmidt: NIH
Jenna Lieberman: NIH
Laila El Khattabi: Institut Cochin Laboratoire de Cytogénétique Constitutionnelle Pré et Post Natale
Rafael Casellas: NIH
Francisco J. Asturias: University of Colorado Anschutz Medical School

Nature Communications, 2021, vol. 12, issue 1, 1-12

Abstract: Abstract The Mediator complex plays an essential and multi-faceted role in regulation of RNA polymerase II transcription in all eukaryotes. Structural analysis of yeast Mediator has provided an understanding of the conserved core of the complex and its interaction with RNA polymerase II but failed to reveal the structure of the Tail module that contains most subunits targeted by activators and repressors. Here we present a molecular model of mammalian (Mus musculus) Mediator, derived from a 4.0 Å resolution cryo-EM map of the complex. The mammalian Mediator structure reveals that the previously unresolved Tail module, which includes a number of metazoan specific subunits, interacts extensively with core Mediator and has the potential to influence its conformation and interactions.

Date: 2021
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DOI: 10.1038/s41467-021-21601-w

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