S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

Joshua G. Liang, Danmei Su, Tian-Zhang Song, Yilan Zeng, Weijin Huang, Jinhua Wu, Rong Xu, Peiwen Luo, Xiaofang Yang, Xiaodong Zhang, Shuangru Luo, Ying Liang, Xinglin Li, Jiaju Huang, Qiang Wang, Xueqin Huang, Qingsong Xu, Mei Luo, Anliang Huang, Dongxia Luo, Chenyan Zhao, Fan Yang, Jian-Bao Han, Yong-Tang Zheng and Peng Liang ()
Additional contact information
Joshua G. Liang: Clover Biopharmaceuticals
Danmei Su: Clover Biopharmaceuticals
Tian-Zhang Song: Chinese Academy of Sciences
Yilan Zeng: Public Health Clinical Center of Chengdu
Weijin Huang: National Institutes for Food and Drug Control (NIFDC)
Jinhua Wu: Clover Biopharmaceuticals
Rong Xu: Clover Biopharmaceuticals
Peiwen Luo: Clover Biopharmaceuticals
Xiaofang Yang: Clover Biopharmaceuticals
Xiaodong Zhang: Clover Biopharmaceuticals
Shuangru Luo: Clover Biopharmaceuticals
Ying Liang: Clover Biopharmaceuticals
Xinglin Li: Clover Biopharmaceuticals
Jiaju Huang: Clover Biopharmaceuticals
Qiang Wang: Clover Biopharmaceuticals
Xueqin Huang: Clover Biopharmaceuticals
Qingsong Xu: Clover Biopharmaceuticals
Mei Luo: Public Health Clinical Center of Chengdu
Anliang Huang: Chengdu Fifth People’s Hospital
Dongxia Luo: Public Health Clinical Center of Chengdu
Chenyan Zhao: National Institutes for Food and Drug Control (NIFDC)
Fan Yang: Chengdu Fifth People’s Hospital
Jian-Bao Han: Chinese Academy of Sciences
Yong-Tang Zheng: Chinese Academy of Sciences
Peng Liang: Clover Biopharmaceuticals

Nature Communications, 2021, vol. 12, issue 1, 1-12

Abstract: Abstract SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. Here we describe S-Trimer, a native-like trimeric subunit vaccine candidate for COVID-19 based on Trimer-Tag technology. Immunization of S-Trimer with either AS03 (oil-in-water emulsion) or CpG 1018 (TLR9 agonist) plus alum adjuvants induced high-level of neutralizing antibodies and Th1-biased cellular immune responses in animal models. Moreover, rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls, based on clinical observations and reduction of viral loads in lungs. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.

Date: 2021
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DOI: 10.1038/s41467-021-21634-1

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