A self-organized synthetic morphogenic liposome responds with shape changes to local light cues

Konstantin Gavriljuk, Bruno Scocozza, Farid Ghasemalizadeh, Hans Seidel, Akhilesh P. Nandan, Manuel Campos-Medina, Malte Schmick, Aneta Koseska and Philippe I. H. Bastiaens ()
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Konstantin Gavriljuk: Max Planck Institute for Molecular Physiology
Bruno Scocozza: Max Planck Institute for Molecular Physiology
Farid Ghasemalizadeh: Max Planck Institute for Molecular Physiology
Hans Seidel: Max Planck Institute for Molecular Physiology
Akhilesh P. Nandan: Max Planck Institute for Molecular Physiology
Manuel Campos-Medina: Max Planck Institute for Molecular Physiology
Malte Schmick: Max Planck Institute for Molecular Physiology
Aneta Koseska: Max Planck Institute for Molecular Physiology
Philippe I. H. Bastiaens: Max Planck Institute for Molecular Physiology

Nature Communications, 2021, vol. 12, issue 1, 1-25

Abstract: Abstract Reconstituting artificial proto-cells capable of transducing extracellular signals into cytoskeletal changes can reveal fundamental principles of how non-equilibrium phenomena in cellular signal transduction affect morphogenesis. Here, we generated a Synthetic Morphogenic Membrane System (SynMMS) by encapsulating a dynamic microtubule (MT) aster and a light-inducible signaling system driven by GTP/ATP chemical potential into cell-sized liposomes. Responding to light cues in analogy to morphogens, this biomimetic design embodies basic principles of localized Rho-GTPase signal transduction that generate an intracellular MT-regulator signaling gradient. Light-induced signaling promotes membrane-deforming growth of MT-filaments by dynamically elevating the membrane-proximal tubulin concentration. The resulting membrane deformations enable recursive coupling of the MT-aster with the signaling system, which generates global self-organized morphologies that reorganize towards local external cues in dependence on prior shape. SynMMS thereby signifies a step towards bio-inspired engineering of self-organized cellular morphogenesis.

Date: 2021
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DOI: 10.1038/s41467-021-21679-2

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