Deciphering the state of immune silence in fatal COVID-19 patients

Pierre Bost, Francesco De Sanctis, Stefania Canè, Stefano Ugel, Katia Donadello, Monica Castellucci, David Eyal, Alessandra Fiore, Cristina Anselmi, Roza Maria Barouni, Rosalinda Trovato, Simone Caligola, Alessia Lamolinara, Manuela Iezzi, Federica Facciotti, Annarita Mazzariol, Davide Gibellini, Pasquale De Nardo, Evelina Tacconelli, Leonardo Gottin, Enrico Polati, Benno Schwikowski, Ido Amit () and Vincenzo Bronte ()
Additional contact information
Pierre Bost: Weizmann Institute of Science
Francesco De Sanctis: University and Hospital Trust of Verona
Stefania Canè: University and Hospital Trust of Verona
Stefano Ugel: University and Hospital Trust of Verona
Katia Donadello: University and Hospital Trust of Verona
Monica Castellucci: University of Verona
David Eyal: Weizmann Institute of Science
Alessandra Fiore: University and Hospital Trust of Verona
Cristina Anselmi: University and Hospital Trust of Verona
Roza Maria Barouni: University and Hospital Trust of Verona
Rosalinda Trovato: University and Hospital Trust of Verona
Simone Caligola: University and Hospital Trust of Verona
Alessia Lamolinara: University of G. D’Annunzio of Chieti-Pescara
Manuela Iezzi: University of G. D’Annunzio of Chieti-Pescara
Federica Facciotti: IEO European Institute of Oncology IRCCS
Annarita Mazzariol: University and Hospital Trust of Verona
Davide Gibellini: University and Hospital Trust of Verona
Pasquale De Nardo: University and Hospital Trust of Verona
Evelina Tacconelli: University and Hospital Trust of Verona
Leonardo Gottin: University and Hospital Trust of Verona
Enrico Polati: University and Hospital Trust of Verona
Benno Schwikowski: Institut Pasteur and CNRS
Ido Amit: Weizmann Institute of Science
Vincenzo Bronte: University and Hospital Trust of Verona

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract Since the beginning of the SARS-CoV-2 pandemic, COVID-19 appeared as a unique disease with unconventional tissue and systemic immune features. Here we show a COVID-19 immune signature associated with severity by integrating single-cell RNA-seq analysis from blood samples and broncho-alveolar lavage fluids with clinical, immunological and functional ex vivo data. This signature is characterized by lung accumulation of naïve lymphoid cells associated with a systemic expansion and activation of myeloid cells. Myeloid-driven immune suppression is a hallmark of COVID-19 evolution, highlighting arginase-1 expression with immune regulatory features of monocytes. Monocyte-dependent and neutrophil-dependent immune suppression loss is associated with fatal clinical outcome in severe patients. Additionally, our analysis shows a lung CXCR6+ effector memory T cell subset is associated with better prognosis in patients with severe COVID-19. In summary, COVID-19-induced myeloid dysregulation and lymphoid impairment establish a condition of ‘immune silence’ in patients with critical COVID-19.

Date: 2021
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-021-21702-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21702-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-21702-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().