Metabolic responses to mild cold acclimation in type 2 diabetes patients

Carlijn M. E. Remie, Michiel P. B. Moonen, Kay H. M. Roumans, Emmani B. M. Nascimento, Anne Gemmink, Bas Havekes, Gert Schaart, Esther Kornips, Peter J. Joris, Vera B. Schrauwen-Hinderling, Joris Hoeks, Sander Kersten, Matthijs K. C. Hesselink, Esther Phielix, Wouter D. van Marken Lichtenbelt and Patrick Schrauwen ()
Additional contact information
Carlijn M. E. Remie: Maastricht University Medical Center
Michiel P. B. Moonen: Maastricht University Medical Center
Kay H. M. Roumans: Maastricht University Medical Center
Emmani B. M. Nascimento: Maastricht University Medical Center
Anne Gemmink: Maastricht University Medical Center
Bas Havekes: Maastricht University Medical Center
Gert Schaart: Maastricht University Medical Center
Esther Kornips: Maastricht University Medical Center
Peter J. Joris: Maastricht University Medical Center
Vera B. Schrauwen-Hinderling: Maastricht University Medical Center
Joris Hoeks: Maastricht University Medical Center
Sander Kersten: Wageningen University
Matthijs K. C. Hesselink: Maastricht University Medical Center
Esther Phielix: Maastricht University Medical Center
Wouter D. van Marken Lichtenbelt: Maastricht University Medical Center
Patrick Schrauwen: Maastricht University Medical Center

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract Mild cold acclimation for 10 days has been previously shown to markedly improve insulin sensitivity in patients with type 2 diabetes. Here we show in a single-arm intervention study (Trialregister.nl ID: NL4469/NTR5711) in nine patients with type 2 diabetes that ten days of mild cold acclimation (16–17 °C) in which observable, overt shivering was prevented, does not result in improved insulin sensitivity, postprandial glucose and lipid metabolism or intrahepatic lipid content and only results in mild effects on overnight fasted fat oxidation, postprandial energy expenditure and aortic augmentation index. The lack of marked metabolic effects in this study is associated with a lack of self-reported shivering and a lack of upregulation of gene expression of muscle activation or muscle contraction pathways in skeletal muscle and suggests that some form of muscle contraction is needed for beneficial effects of mild cold acclimation.

Date: 2021
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-21813-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21813-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-21813-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().