Development of a mugineic acid family phytosiderophore analog as an iron fertilizer

Motofumi Suzuki, Atsumi Urabe, Sayaka Sasaki, Ryo Tsugawa, Satoshi Nishio, Haruka Mukaiyama, Yoshiko Murata, Hiroshi Masuda, May Sann Aung, Akane Mera, Masaki Takeuchi, Keijo Fukushima, Michika Kanaki, Kaori Kobayashi, Yuichi Chiba, Binod Babu Shrestha, Hiromi Nakanishi, Takehiro Watanabe, Atsushi Nakayama, Hiromichi Fujino, Takanori Kobayashi, Keiji Tanino, Naoko K. Nishizawa and Kosuke Namba ()
Additional contact information
Motofumi Suzuki: Aichi Steel Corporation
Atsumi Urabe: Tokushima University
Sayaka Sasaki: Tokushima University
Ryo Tsugawa: Tokushima University
Satoshi Nishio: Tokushima University
Haruka Mukaiyama: Tokushima University
Yoshiko Murata: Bioorganic Research Institute, Suntory Foundation for Life Sciences
Hiroshi Masuda: Ishikawa Prefectural University
May Sann Aung: Ishikawa Prefectural University
Akane Mera: Aichi Steel Corporation
Masaki Takeuchi: Tokushima University
Keijo Fukushima: Tokushima University
Michika Kanaki: Hokkaido University
Kaori Kobayashi: Hokkaido University
Yuichi Chiba: The University of Tokyo
Binod Babu Shrestha: Tokushima University
Hiromi Nakanishi: The University of Tokyo
Takehiro Watanabe: Bioorganic Research Institute, Suntory Foundation for Life Sciences
Atsushi Nakayama: Tokushima University
Hiromichi Fujino: Tokushima University
Takanori Kobayashi: Ishikawa Prefectural University
Keiji Tanino: Hokkaido University
Naoko K. Nishizawa: Ishikawa Prefectural University
Kosuke Namba: Tokushima University

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Iron (Fe) is an essential nutrient, but is poorly bioavailable because of its low solubility in alkaline soils; this leads to reduced agricultural productivity. To overcome this problem, we first showed that the soil application of synthetic 2′-deoxymugineic acid, a natural phytosiderophore from the Poaceae, can recover Fe deficiency in rice grown in calcareous soil. However, the high cost and poor stability of synthetic 2′-deoxymugineic acid preclude its agricultural use. In this work, we develop a more stable and less expensive analog, proline-2′-deoxymugineic acid, and demonstrate its practical synthesis and transport of its Fe-chelated form across the plasma membrane by Fe(III)•2’-deoxymugineic acid transporters. Possibility of its use as an iron fertilizer on alkaline soils is supported by promotion of rice growth in a calcareous soil by soil application of metal free proline-2’-deoxymugineic acid.

Date: 2021
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DOI: 10.1038/s41467-021-21837-6

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