A randomised controlled trial to reduce highest priority critically important antimicrobial prescription in companion animals

David A. Singleton (), Angela Rayner, Bethaney Brant, Steven Smyth, Peter-John M. Noble, Alan D. Radford and Gina L. Pinchbeck
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David A. Singleton: University of Liverpool, Leahurst Campus, Chester High Road
Angela Rayner: CVS (UK) Limited, 1 Owen Road
Bethaney Brant: University of Liverpool, Leahurst Campus, Chester High Road
Steven Smyth: University of Liverpool, Leahurst Campus, Chester High Road
Peter-John M. Noble: University of Liverpool, Leahurst Campus, Chester High Road
Alan D. Radford: University of Liverpool, Leahurst Campus, Chester High Road
Gina L. Pinchbeck: University of Liverpool, Leahurst Campus, Chester High Road

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract Robust evidence supporting strategies for companion animal antimicrobial stewardship is limited, despite frequent prescription of highest priority critically important antimicrobials (HPCIA). Here we describe a randomised controlled trial where electronic prescription data were utilised (August 2018–January 2019) to identify above average HPCIA-prescribing practices (n = 60), which were randomly assigned into a control group (CG) and two intervention groups. In March 2019, the light intervention group (LIG) and heavy intervention group (HIG) were notified of their above average status, and were provided with educational material (LIG, HIG), in-depth benchmarking (HIG), and follow-up meetings (HIG). Following notification, follow-up monitoring lasted for eight months (April–November 2019; post-intervention period) for all intervention groups, though HIG practices were able to access further support (i.e., follow-up meetings) for the first six of these months if requested. Post-intervention, in the HIG a 23.5% and 39.0% reduction in canine (0.5% of total consultations, 95% confidence interval, 0.4-0.6, P = 0.04) and feline (4.4%, 3.4-5.3, P

Date: 2021
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DOI: 10.1038/s41467-021-21864-3

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