All-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis

Kyunghun Kim, Ho Joong Kim, Haozhe Zhang, Woohyun Park, Dawn Meyer, Min Ku Kim, Bongjoong Kim, Heun Park, Baoxing Xu (), Pete Kollbaum (), Bryan W. Boudouris () and Chi Hwan Lee ()
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Kyunghun Kim: Purdue University
Ho Joong Kim: Purdue University
Haozhe Zhang: University of Virginia
Woohyun Park: Purdue University
Dawn Meyer: Indiana University
Min Ku Kim: Purdue University
Bongjoong Kim: Purdue University
Heun Park: Purdue University
Baoxing Xu: University of Virginia
Pete Kollbaum: Indiana University
Bryan W. Boudouris: Purdue University
Chi Hwan Lee: Purdue University

Nature Communications, 2021, vol. 12, issue 1, 1-11

Abstract: Abstract Electroretinogram examinations serve as routine clinical procedures in ophthalmology for the diagnosis and management of many ocular diseases. However, the rigid form factor of current corneal sensors produces a mismatch with the soft, curvilinear, and exceptionally sensitive human cornea, which typically requires the use of topical anesthesia and a speculum for pain management and safety. Here we report a design of an all-printed stretchable corneal sensor built on commercially-available disposable soft contact lenses that can intimately and non-invasively interface with the corneal surface of human eyes. The corneal sensor is integrated with soft contact lenses via an electrochemical anchoring mechanism in a seamless manner that ensures its mechanical and chemical reliability. Thus, the resulting device enables the high-fidelity recording of full-field electroretinogram signals in human eyes without the need of topical anesthesia or a speculum. The device, superior to clinical standards in terms of signal quality and comfortability, is expected to address unmet clinical needs in the field of ocular electrodiagnosis.

Date: 2021
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DOI: 10.1038/s41467-021-21916-8

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