A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing

Jian Zhang, Yongjun Zheng, Jimmy Lee, Jieyu Hua, Shilong Li, Ananth Panchamukhi, Jiping Yue, Xuewen Gou, Zhaofan Xia, Linyong Zhu () and Xiaoyang Wu ()
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Jian Zhang: Ben May Department for Cancer Research
Yongjun Zheng: East China University of Science & Technology
Jimmy Lee: Ben May Department for Cancer Research
Jieyu Hua: East China University of Science & Technology
Shilong Li: Ben May Department for Cancer Research
Ananth Panchamukhi: Ben May Department for Cancer Research
Jiping Yue: Ben May Department for Cancer Research
Xuewen Gou: Ben May Department for Cancer Research
Zhaofan Xia: Burns Center of Changhai Hospital
Linyong Zhu: East China University of Science & Technology
Xiaoyang Wu: Ben May Department for Cancer Research

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Effective healing of skin wounds is essential for our survival. Although skin has strong regenerative potential, dysfunctional and disfiguring scars can result from aberrant wound repair. Skin scarring involves excessive deposition and misalignment of ECM (extracellular matrix), increased cellularity, and chronic inflammation. Transforming growth factor-β (TGFβ) signaling exerts pleiotropic effects on wound healing by regulating cell proliferation, migration, ECM production, and the immune response. Although blocking TGFβ signaling can reduce tissue fibrosis and scarring, systemic inhibition of TGFβ can lead to significant side effects and inhibit wound re-epithelization. In this study, we develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-β inhibitor to achieve spatiotemporal specificity for skin wounds. The material enhances skin wound closure while effectively suppressing scar formation in murine skin wounds and large animal preclinical models. Our study presents a strategy for scarless wound repair.

Date: 2021
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DOI: 10.1038/s41467-021-21964-0

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