A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery

Shanshan Hu, Xibo Pei, Lunliang Duan, Zhou Zhu, Yanhua Liu, Junyu Chen, Tao Chen, Ping Ji, Qianbing Wan () and Jian Wang ()
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Shanshan Hu: West China Hospital of Stomatology, Sichuan University
Xibo Pei: West China Hospital of Stomatology, Sichuan University
Lunliang Duan: Chongqing Jiaotong University
Zhou Zhu: West China Hospital of Stomatology, Sichuan University
Yanhua Liu: West China Hospital of Stomatology, Sichuan University
Junyu Chen: West China Hospital of Stomatology, Sichuan University
Tao Chen: Stomatological Hospital of Chongqing Medical University
Ping Ji: Stomatological Hospital of Chongqing Medical University
Qianbing Wan: West China Hospital of Stomatology, Sichuan University
Jian Wang: West China Hospital of Stomatology, Sichuan University

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract Administration of drugs via the buccal route has attracted much attention in recent years. However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge. Here, we propose a mussel-inspired mucoadhesive film. Ex vivo models show that this film can achieve strong adhesion to wet buccal tissues (up to 38.72 ± 10.94 kPa). We also demonstrate that the adhesion mechanism of this film relies on both physical association and covalent bonding between the film and mucus. Additionally, the film with incorporated polydopamine nanoparticles shows superior advantages for transport across the mucosal barrier, with improved drug bioavailability (~3.5-fold greater than observed with oral delivery) and therapeutic efficacy in oral mucositis models (~6.0-fold improvement in wound closure at day 5 compared with that observed with no treatment). We anticipate that this platform might aid the development of tissue adhesives and inspire the design of nanoparticle-based buccal delivery systems.

Date: 2021
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DOI: 10.1038/s41467-021-21989-5

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