Photonic resonator interferometric scattering microscopy

Nantao Li, Taylor D. Canady, Qinglan Huang, Xing Wang, Glenn A. Fried and Brian T. Cunningham ()
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Nantao Li: University of Illinois at Urbana-Champaign
Taylor D. Canady: University of Illinois at Urbana-Champaign
Qinglan Huang: University of Illinois at Urbana-Champaign
Xing Wang: University of Illinois at Urbana-Champaign
Glenn A. Fried: University of Illinois at Urbana-Champaign
Brian T. Cunningham: University of Illinois at Urbana-Champaign

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract Interferometric scattering microscopy is increasingly employed in biomedical research owing to its extraordinary capability of detecting nano-objects individually through their intrinsic elastic scattering. To significantly improve the signal-to-noise ratio without increasing illumination intensity, we developed photonic resonator interferometric scattering microscopy (PRISM) in which a dielectric photonic crystal (PC) resonator is utilized as the sample substrate. The scattered light is amplified by the PC through resonant near-field enhancement, which then interferes with the

Date: 2021
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DOI: 10.1038/s41467-021-21999-3

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