Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection

Zhongfang Wang, Xiaoyun Yang, Jiaying Zhong, Yumin Zhou, Zhiqiang Tang, Haibo Zhou, Jun He, Xinyue Mei, Yonghong Tang, Bijia Lin, Zhenjun Chen, James McCluskey, Ji Yang, Alexandra J. Corbett and Pixin Ran ()
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Zhongfang Wang: Guangzhou Medical University
Xiaoyun Yang: Guangzhou Medical University
Jiaying Zhong: Guangzhou Medical University
Yumin Zhou: Guangzhou Medical University
Zhiqiang Tang: The Second Peoples Hospital of Changde City
Haibo Zhou: The Sixth Affiliated Hospital of Guangzhou Medical University
Jun He: Affiliated Nanhua Hospital of University of South China
Xinyue Mei: Guangzhou Medical University
Yonghong Tang: Affiliated Nanhua Hospital of University of South China
Bijia Lin: Guangzhou Medical University
Zhenjun Chen: University of Melbourne, Melbourne
James McCluskey: University of Melbourne, Melbourne
Ji Yang: Guangzhou Medical University
Alexandra J. Corbett: University of Melbourne, Melbourne
Pixin Ran: Guangzhou Medical University

Nature Communications, 2021, vol. 12, issue 1, 1-8

Abstract: Abstract T-cell immunity is important for recovery from COVID-19 and provides heightened immunity for re-infection. However, little is known about the SARS-CoV-2-specific T-cell immunity in virus-exposed individuals. Here we report virus-specific CD4+ and CD8+ T-cell memory in recovered COVID-19 patients and close contacts. We also demonstrate the size and quality of the memory T-cell pool of COVID-19 patients are larger and better than those of close contacts. However, the proliferation capacity, size and quality of T-cell responses in close contacts are readily distinguishable from healthy donors, suggesting close contacts are able to gain T-cell immunity against SARS-CoV-2 despite lacking a detectable infection. Additionally, asymptomatic and symptomatic COVID-19 patients contain similar levels of SARS-CoV-2-specific T-cell memory. Overall, this study demonstrates the versatility and potential of memory T cells from COVID-19 patients and close contacts, which may be important for host protection.

Date: 2021
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DOI: 10.1038/s41467-021-22036-z

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