A wearable patch for continuous analysis of thermoregulatory sweat at rest

Hnin Yin Yin Nyein, Mallika Bariya, Brandon Tran, Christine Heera Ahn, Brenden Janatpour Brown, Wenbo Ji, Noelle Davis and Ali Javey ()
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Hnin Yin Yin Nyein: University of California
Mallika Bariya: University of California
Brandon Tran: University of California
Christine Heera Ahn: University of California
Brenden Janatpour Brown: University of California
Wenbo Ji: University of California
Noelle Davis: University of California
Ali Javey: University of California

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract The body naturally and continuously secretes sweat for thermoregulation during sedentary and routine activities at rates that can reflect underlying health conditions, including nerve damage, autonomic and metabolic disorders, and chronic stress. However, low secretion rates and evaporation pose challenges for collecting resting thermoregulatory sweat for non-invasive analysis of body physiology. Here we present wearable patches for continuous sweat monitoring at rest, using microfluidics to combat evaporation and enable selective monitoring of secretion rate. We integrate hydrophilic fillers for rapid sweat uptake into the sensing channel, reducing required sweat accumulation time towards real-time measurement. Along with sweat rate sensors, we integrate electrochemical sensors for pH, Cl−, and levodopa monitoring. We demonstrate patch functionality for dynamic sweat analysis related to routine activities, stress events, hypoglycemia-induced sweating, and Parkinson’s disease. By enabling sweat analysis compatible with sedentary, routine, and daily activities, these patches enable continuous, autonomous monitoring of body physiology at rest.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22109-z

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DOI: 10.1038/s41467-021-22109-z

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