Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages

Deyanira Pérez-Morales and Víctor H. Bustamante ()
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Deyanira Pérez-Morales: Universidad Nacional Autónoma de México
Víctor H. Bustamante: Universidad Nacional Autónoma de México

Nature Communications, 2021, vol. 12, issue 1, 1-3

Abstract: Replication inside macrophages is crucial for systemic dissemination of Salmonella in hosts. In a Nature Communications article, Jiang et al. show that Salmonella stimulates glycolysis and represses serine synthesis in macrophages, leading to accumulation of host glycolytic intermediates that the bacteria use as carbon source and as cues for its replication.

Date: 2021
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DOI: 10.1038/s41467-021-22198-w

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