2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases

Wei Feng, Xiuguo Han, Hui Hu, Meiqi Chang, Li Ding, Huijing Xiang, Yu Chen () and Yuehua Li ()
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Wei Feng: Shanghai University
Xiuguo Han: Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Hui Hu: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Meiqi Chang: Chinese Academy of Sciences
Li Ding: Chinese Academy of Sciences
Huijing Xiang: Shanghai University
Yu Chen: Shanghai University
Yuehua Li: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital

Nature Communications, 2021, vol. 12, issue 1, 1-16

Abstract: Abstract Reactive oxygen species (ROS) are generated and consumed in living organism for normal metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been involved in pathogenesis and progression of various human diseases. Here, we reported a two-dimensional (2D) vanadium carbide (V2C) MXene nanoenzyme (MXenzyme) that can mimic up to six naturally-occurring enzymes, including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione peroxidase (GPx), thiol peroxidase (TPx) and haloperoxidase (HPO). Based on these enzyme-mimicking properties, the constructed 2D V2C MXenzyme not only possesses high biocompatibility but also exhibits robust in vitro cytoprotection against oxidative stress. Importantly, 2D V2C MXenzyme rebuilds the redox homeostasis without perturbing the endogenous antioxidant status and relieves ROS-induced damage with benign in vivo therapeutic effects, as demonstrated in both inflammation and neurodegeneration animal models. These findings open an avenue to enable the use of MXenzyme as a remedial nanoplatform to treat ROS-mediated inflammatory and neurodegenerative diseases.

Date: 2021
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DOI: 10.1038/s41467-021-22278-x

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