Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors

Baharak Bahmani, Hua Gong, Brian T. Luk, Kristofer J. Haushalter, Ethel DeTeresa, Mark Previti, Jiarong Zhou, Weiwei Gao, Jack D. Bui, Liangfang Zhang, Ronnie H. Fang () and Jie Zhang ()
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Baharak Bahmani: Cello Therapeutics, Inc.
Hua Gong: University of California San Diego
Brian T. Luk: Cello Therapeutics, Inc.
Kristofer J. Haushalter: Cello Therapeutics, Inc.
Ethel DeTeresa: Cello Therapeutics, Inc.
Mark Previti: Cello Therapeutics, Inc.
Jiarong Zhou: University of California San Diego
Weiwei Gao: University of California San Diego
Jack D. Bui: University of California San Diego
Liangfang Zhang: University of California San Diego
Ronnie H. Fang: University of California San Diego
Jie Zhang: Cello Therapeutics, Inc.

Nature Communications, 2021, vol. 12, issue 1, 1-12

Abstract: Abstract Intratumoral immunotherapy is an emerging modality for the treatment of solid tumors. Toll-like receptor (TLR) agonists have shown promise for eliciting immune responses, but systemic administration often results in the development of adverse side effects. Herein, we investigate whether localized delivery of the TLR agonist, resiquimod (R848), via platelet membrane-coated nanoparticles (PNP-R848) elicits antitumor responses. The membrane coating provides a means of enhancing interactions with the tumor microenvironment, thereby maximizing the activity of R848. Intratumoral administration of PNP-R848 strongly enhances local immune activation and leads to complete tumor regression in a colorectal tumor model, while providing protection against repeated tumor re-challenges. Moreover, treatment of an aggressive breast cancer model with intratumoral PNP-R848 delays tumor growth and inhibits lung metastasis. Our findings highlight the promise of locally delivering immunostimulatory payloads using biomimetic nanocarriers, which possess advantages such as enhanced biocompatibility and natural targeting affinities.

Date: 2021
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DOI: 10.1038/s41467-021-22311-z

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