Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C

Shoeib Moradi, Sanda Stankovic, Geraldine M. O’Connor, Phillip Pymm, Bruce J. MacLachlan, Camilla Faoro, Christelle Retière, Lucy C. Sullivan, Philippa M. Saunders, Jacqueline Widjaja, Shea Cox-Livingstone, Jamie Rossjohn (), Andrew G. Brooks () and Julian P. Vivian ()
Additional contact information
Shoeib Moradi: Monash University
Sanda Stankovic: The University of Melbourne
Geraldine M. O’Connor: School of Medicine, University of Central Lancashire
Phillip Pymm: Monash University
Bruce J. MacLachlan: Monash University
Camilla Faoro: Monash University
Christelle Retière: Etablissement Français du Sang, Nantes
Lucy C. Sullivan: The University of Melbourne
Philippa M. Saunders: The University of Melbourne
Jacqueline Widjaja: The University of Melbourne
Shea Cox-Livingstone: The University of Melbourne
Jamie Rossjohn: Monash University
Andrew G. Brooks: The University of Melbourne
Julian P. Vivian: Monash University

Nature Communications, 2021, vol. 12, issue 1, 1-11

Abstract: Abstract The closely related inhibitory killer-cell immunoglobulin-like receptors (KIR), KIR2DL2 and KIR2DL3, regulate the activation of natural killer cells (NK) by interacting with the human leukocyte antigen-C1 (HLA-C1) group of molecules. KIR2DL2, KIR2DL3 and HLA-C1 are highly polymorphic, with this variation being associated with differences in the onset and progression of some human diseases. However, the molecular bases underlying these associations remain unresolved. Here, we determined the crystal structures of KIR2DL2 and KIR2DL3 in complex with HLA-C*07:02 presenting a self-epitope. KIR2DL2 differed from KIR2DL3 in docking modality over HLA-C*07:02 that correlates with variabilty of recognition of HLA-C1 allotypes. Mutagenesis assays indicated differences in the mechanism of HLA-C1 allotype recognition by KIR2DL2 and KIR2DL3. Similarly, HLA-C1 allotypes differed markedly in their capacity to inhibit activation of primary NK cells. These functional differences derive, in part, from KIR2DS2 suggesting KIR2DL2 and KIR2DL3 binding geometries combine with other factors to distinguish HLA-C1 functional recognition.

Date: 2021
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DOI: 10.1038/s41467-021-22359-x

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