Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

William S. Harris (), Nathan L. Tintle, Fumiaki Imamura, Frank Qian, Andres V. Ardisson Korat, Matti Marklund, Luc Djoussé, Julie K. Bassett, Pierre-Hugues Carmichael, Yun-Yu Chen, Yoichiro Hirakawa, Leanne K. Küpers, Federica Laguzzi, Maria Lankinen, Rachel A. Murphy, Cécilia Samieri, Mackenzie K. Senn, Peilin Shi, Jyrki K. Virtanen, Ingeborg A. Brouwer, Kuo-Liong Chien, Gudny Eiriksdottir, Nita G. Forouhi, Johanna M. Geleijnse, Graham G. Giles, Vilmundur Gudnason, Catherine Helmer, Allison Hodge, Rebecca Jackson, Kay-Tee Khaw, Markku Laakso, Heidi Lai, Danielle Laurin, Karin Leander, Joan Lindsay, Renata Micha, Jaako Mursu, Toshiharu Ninomiya, Wendy Post, Bruce M. Psaty, Ulf Risérus, Jennifer G. Robinson, Aladdin H. Shadyab, Linda Snetselaar, Aleix Sala-Vila, Yangbo Sun, Lyn M. Steffen, Michael Y. Tsai, Nicholas J. Wareham, Alexis C. Wood, Jason H. Y. Wu, Frank Hu, Qi Sun, David S. Siscovick, Rozenn N. Lemaitre and Dariush Mozaffarian
Additional contact information
William S. Harris: University of South Dakota
Nathan L. Tintle: The Fatty Acid Research Institute
Fumiaki Imamura: University of Cambridge School of Clinical Medicine
Frank Qian: Harvard T.H. Chan School of Public Health and Harvard Medical School
Andres V. Ardisson Korat: Brigham and Women’s Hospital, and Harvard Medical School
Matti Marklund: University New South Wales
Luc Djoussé: Brigham and Women’s Hospital, and Harvard Medical School
Julie K. Bassett: Cancer Council Victoria
Pierre-Hugues Carmichael: Centre D’excellence Sur le Vieillissement de Québec, CIUSSS-CN
Yun-Yu Chen: National Taiwan University
Yoichiro Hirakawa: Kyushu University
Leanne K. Küpers: Wageningen University
Federica Laguzzi: Karolinska Institute
Maria Lankinen: University of Eastern Finland
Rachel A. Murphy: University of British Columbia
Cécilia Samieri: University of Bordeaux
Mackenzie K. Senn: Baylor College of Medicine
Peilin Shi: Tufts University
Jyrki K. Virtanen: University of Eastern Finland
Ingeborg A. Brouwer: Vrije Universiteit Amsterdam, Amsterdam and Amsterdam Public Health Research Institute
Kuo-Liong Chien: National Taiwan University
Gudny Eiriksdottir: Icelandic Heart Association
Nita G. Forouhi: University of Cambridge School of Clinical Medicine
Johanna M. Geleijnse: Wageningen University
Graham G. Giles: The University of Melbourne
Vilmundur Gudnason: Icelandic Heart Association
Catherine Helmer: University of Bordeaux
Allison Hodge: The University of Melbourne
Rebecca Jackson: The Ohio State University
Kay-Tee Khaw: University of Cambridge School of Clinical Medicine
Markku Laakso: University of Eastern Finland
Heidi Lai: Tufts University
Danielle Laurin: Centre D’excellence Sur le Vieillissement de Québec, CIUSSS-CN
Karin Leander: Karolinska Institute
Joan Lindsay: University of Ottawa
Renata Micha: Tufts University
Jaako Mursu: University of Eastern Finland
Toshiharu Ninomiya: Kyushu University
Wendy Post: Cancer Council Victoria
Bruce M. Psaty: University of Washington
Ulf Risérus: Uppsala University
Jennifer G. Robinson: University of Iowa
Aladdin H. Shadyab: University of California San Diego School of Medicine
Linda Snetselaar: University of Iowa
Aleix Sala-Vila: The Fatty Acid Research Institute
Yangbo Sun: University of Iowa
Lyn M. Steffen: University of Minnesota
Michael Y. Tsai: University of Minnesota
Nicholas J. Wareham: University of Cambridge School of Clinical Medicine
Alexis C. Wood: Baylor College of Medicine
Jason H. Y. Wu: University New South Wales
Frank Hu: Harvard T.H. Chan School of Public Health and Harvard Medical School
Qi Sun: Harvard T.H. Chan School of Public Health and Harvard Medical School
David S. Siscovick: The New York Academy of Medicine
Rozenn N. Lemaitre: University of Washington
Dariush Mozaffarian: Tufts University

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15–18%, at least p

Date: 2021
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DOI: 10.1038/s41467-021-22370-2

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