Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism

Ming-Liang Lee, Hirokazu Matsunaga, Yuki Sugiura, Takahiro Hayasaka, Izumi Yamamoto, Taiga Ishimoto, Daigo Imoto, Makoto Suematsu, Norifumi Iijima, Kazuhiro Kimura, Sabrina Diano and Chitoku Toda ()
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Ming-Liang Lee: Hokkaido University
Hirokazu Matsunaga: Hokkaido University
Yuki Sugiura: Keio University School of Medicine, Shinjuku-ku
Takahiro Hayasaka: Hokkaido University
Izumi Yamamoto: Hokkaido University
Taiga Ishimoto: Hokkaido University
Daigo Imoto: Hokkaido University
Makoto Suematsu: Keio University School of Medicine, Shinjuku-ku
Norifumi Iijima: National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki
Kazuhiro Kimura: Hokkaido University
Sabrina Diano: Columbia University Irving Medical Center
Chitoku Toda: Hokkaido University

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract The hypothalamus plays a central role in monitoring and regulating systemic glucose metabolism. The brain is enriched with phospholipids containing poly-unsaturated fatty acids, which are biologically active in physiological regulation. Here, we show that intraperitoneal glucose injection induces changes in hypothalamic distribution and amounts of phospholipids, especially arachidonic-acid-containing phospholipids, that are then metabolized to produce prostaglandins. Knockdown of cytosolic phospholipase A2 (cPLA2), a key enzyme for generating arachidonic acid from phospholipids, in the hypothalamic ventromedial nucleus (VMH), lowers insulin sensitivity in muscles during regular chow diet (RCD) feeding. Conversely, the down-regulation of glucose metabolism by high fat diet (HFD) feeding is improved by knockdown of cPLA2 in the VMH through changing hepatic insulin sensitivity and hypothalamic inflammation. Our data suggest that cPLA2-mediated hypothalamic phospholipid metabolism is critical for controlling systemic glucose metabolism during RCD, while continuous activation of the same pathway to produce prostaglandins during HFD deteriorates glucose metabolism.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22431-6

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DOI: 10.1038/s41467-021-22431-6

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