Comprehensive omic characterization of breast cancer in Mexican-Hispanic women

Sandra L. Romero-Cordoba (), Ivan Salido-Guadarrama, Rosa Rebollar-Vega, Veronica Bautista-Piña, Carlos Dominguez-Reyes, Alberto Tenorio-Torres, Felipe Villegas-Carlos, Juan C. Fernández-López, Laura Uribe-Figueroa, Luis Alfaro-Ruiz and Alfredo Hidalgo-Miranda ()
Additional contact information
Sandra L. Romero-Cordoba: Universidad Nacional Autónoma de México
Ivan Salido-Guadarrama: Laboratorio de Biología Computacional, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas
Rosa Rebollar-Vega: National Institute of Genomic Medicine
Veronica Bautista-Piña: Instituto de Enfermedades de la Mama FUCAM
Carlos Dominguez-Reyes: Instituto de Enfermedades de la Mama FUCAM
Alberto Tenorio-Torres: Instituto de Enfermedades de la Mama FUCAM
Felipe Villegas-Carlos: Instituto de Enfermedades de la Mama FUCAM
Juan C. Fernández-López: National Institute of Genomic Medicine
Laura Uribe-Figueroa: National Institute of Genomic Medicine
Luis Alfaro-Ruiz: National Institute of Genomic Medicine
Alfredo Hidalgo-Miranda: National Institute of Genomic Medicine

Nature Communications, 2021, vol. 12, issue 1, 1-19

Abstract: Abstract Breast cancer is a heterogeneous pathology, but the genomic basis of its variability remains poorly understood in populations other than Caucasians. Here, through DNA and RNA portraits we explored the molecular features of breast cancers in a set of Hispanic-Mexican (HM) women and compared them to public multi-ancestry datasets. HM patients present an earlier onset of the disease, particularly in aggressive clinical subtypes, compared to non-Hispanic women. The age-related COSMIC signature 1 was more frequent in HM women than in those from other ancestries. We found the AKT1E17K hotspot mutation in 8% of the HM women and identify the AKT1/PIK3CA axis as a potentially druggable target. Also, HM luminal breast tumors present an enhanced immunogenic phenotype compared to Asiatic and Caucasian tumors. This study is an initial effort to include patients from Hispanic populations in the research of breast cancer etiology and biology to further understand breast cancer disparities.

Date: 2021
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-021-22478-5 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22478-5

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-22478-5

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().