SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer

Xiaowen Wang, Hong Zhang, Russell Sapio, Jun Yang, Justin Wong, Xin Zhang, Jessie Y. Guo, Sharon Pine, Holly Remmen, Hong Li, Eileen White, Chen Liu, Megerditch Kiledjian, Dimitri G. Pestov () and X. F. Steven Zheng ()
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Xiaowen Wang: Rutgers, The State University of New Jersey
Hong Zhang: Rutgers, The State University of New Jersey
Russell Sapio: Rowan University
Jun Yang: Rutgers, The State University of New Jersey
Justin Wong: Rutgers, The State University of New Jersey
Xin Zhang: Rutgers, The State University of New Jersey
Jessie Y. Guo: Rutgers, The State University of New Jersey
Sharon Pine: Rutgers, The State University of New Jersey
Holly Remmen: Oklahoma Medical Research Foundation
Hong Li: Rutgers, The State University of New Jersey
Eileen White: Rutgers, The State University of New Jersey
Chen Liu: Rutgers, The State University of New Jersey
Megerditch Kiledjian: Rutgers, The State University of New Jersey
Dimitri G. Pestov: Rowan University
X. F. Steven Zheng: Rutgers, The State University of New Jersey

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract SOD1 is known as the major cytoplasmic superoxide dismutase and an anticancer target. However, the role of SOD1 in cancer is not fully understood. Herein we describe the generation of an inducible Sod1 knockout in KRAS-driven NSCLC mouse model. Sod1 knockout markedly reduces tumor burden in vivo and blocks growth of KRAS mutant NSCLC cells in vitro. Intriguingly, SOD1 is enriched in the nucleus and notably in the nucleolus of NSCLC cells. The nuclear and nucleolar, not cytoplasmic, form of SOD1 is essential for lung cancer cell proliferation. Moreover, SOD1 interacts with PeBoW complex and controls its assembly necessary for pre-60S ribosomal subunit maturation. Mechanistically, SOD1 regulates co-localization of PeBoW with and processing of pre-rRNA, and maturation of cytoplasmic 60S ribosomal subunits in KRAS mutant lung cancer cells. Collectively, our study unravels a nuclear SOD1 function essential for ribosome biogenesis and proliferation in KRAS-driven lung cancer.

Date: 2021
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DOI: 10.1038/s41467-021-22480-x

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