Cell barrier function of resident peritoneal macrophages in post-operative adhesions

Tomoya Ito (), Yusuke Shintani, Laura Fields, Manabu Shiraishi, Mihai‑Nicolae Podaru, Satoshi Kainuma, Kizuku Yamashita, Kazuya Kobayashi, Mauro Perretti, Fiona Lewis-McDougall and Ken Suzuki ()
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Tomoya Ito: Queen Mary University of London
Yusuke Shintani: Queen Mary University of London
Laura Fields: Queen Mary University of London
Manabu Shiraishi: Queen Mary University of London
Mihai‑Nicolae Podaru: Queen Mary University of London
Satoshi Kainuma: Queen Mary University of London
Kizuku Yamashita: Queen Mary University of London
Kazuya Kobayashi: Queen Mary University of London
Mauro Perretti: Queen Mary University of London
Fiona Lewis-McDougall: Queen Mary University of London
Ken Suzuki: Queen Mary University of London

Nature Communications, 2021, vol. 12, issue 1, 1-12

Abstract: Abstract Post-operative adhesions are a leading cause of abdominal surgery-associated morbidity. Exposed fibrin clots on the damaged peritoneum, in which the mesothelial barrier is disrupted, readily adhere to surrounding tissues, resulting in adhesion formation. Here we show that resident F4/80HighCD206− peritoneal macrophages promptly accumulate on the lesion and form a ‘macrophage barrier’ to shield fibrin clots in place of the lost mesothelium in mice. Depletion of this macrophage subset or blockage of CD11b impairs the macrophage barrier and exacerbates adhesions. The macrophage barrier is usually insufficient to fully preclude the adhesion formation; however, it could be augmented by IL-4-based treatment or adoptive transfer of this macrophage subset, resulting in robust prevention of adhesions. By contrast, monocyte-derived recruited peritoneal macrophages are not involved in the macrophage barrier. These results highlight a previously unidentified cell barrier function of a specific macrophage subset, also proposing an innovative approach to prevent post-operative adhesions.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22536-y

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DOI: 10.1038/s41467-021-22536-y

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