Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer

Zhiyong Wang, Yusuke Goto, Michael M. Allevato, Victoria H. Wu, Robert Saddawi-Konefka (), Mara Gilardi, Diego Alvarado, Bryan S. Yung, Aoife O’Farrell, Alfredo A. Molinolo, Umamaheswar Duvvuri, Jennifer R. Grandis, Joseph A. Califano, Ezra E. W. Cohen and J. Silvio Gutkind ()
Additional contact information
Zhiyong Wang: University of California San Diego
Yusuke Goto: University of California San Diego
Michael M. Allevato: University of California San Diego
Victoria H. Wu: University of California San Diego
Robert Saddawi-Konefka: University of California San Diego
Mara Gilardi: University of California San Diego
Diego Alvarado: Celldex Therapeutics
Bryan S. Yung: University of California San Diego
Aoife O’Farrell: University of California San Diego
Alfredo A. Molinolo: University of California San Diego
Umamaheswar Duvvuri: University of Pittsburgh School of Medicine
Jennifer R. Grandis: University of California San Francisco
Joseph A. Califano: University of California San Diego
Ezra E. W. Cohen: University of California San Diego
J. Silvio Gutkind: University of California San Diego

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Immune checkpoint blockade (ICB) therapy has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment, but

Date: 2021
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/s41467-021-22619-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22619-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-22619-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().