The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation

Richard J. Acton, Wei Yuan, Fei Gao, Yudong Xia, Emma Bourne, Eva Wozniak, Jordana Bell, Karen Lillycrop, Jun Wang, Elaine Dennison, Nicholas C. Harvey, Charles A. Mein, Tim D. Spector, Pirro G. Hysi, Cyrus Cooper and Christopher G. Bell ()
Additional contact information
Richard J. Acton: Queen Mary University of London
Wei Yuan: King’s College London
Fei Gao: BGI-Shenzhen
Yudong Xia: BGI-Shenzhen
Emma Bourne: Queen Mary University of London
Eva Wozniak: Queen Mary University of London
Jordana Bell: King’s College London
Karen Lillycrop: University of Southampton
Jun Wang: Shenzhen Digital Life Institute
Elaine Dennison: University of Southampton
Nicholas C. Harvey: University of Southampton
Charles A. Mein: Queen Mary University of London
Tim D. Spector: King’s College London
Pirro G. Hysi: King’s College London
Cyrus Cooper: University of Southampton
Christopher G. Bell: Queen Mary University of London

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract The epigenome has been shown to deteriorate with age, potentially impacting on ageing-related disease. tRNA, while arising from only ˜46 kb (

Date: 2021
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DOI: 10.1038/s41467-021-22639-6

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