Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences

Homeira Moradi Chameh, Scott Rich, Lihua Wang, Fu- Der Chen, Liang Zhang, Peter L. Carlen, Shreejoy J. Tripathy and Taufik A. Valiante ()
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Homeira Moradi Chameh: University Health Network
Scott Rich: University Health Network
Lihua Wang: University Health Network
Fu- Der Chen: University of Toronto
Liang Zhang: University Health Network
Peter L. Carlen: University Health Network
Shreejoy J. Tripathy: Centre for Addiction and Mental Health
Taufik A. Valiante: University Health Network

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract In the human neocortex coherent interlaminar theta oscillations are driven by deep cortical layers, suggesting neurons in these layers exhibit distinct electrophysiological properties. To characterize this potential distinctiveness, we use in vitro whole-cell recordings from cortical layers 2 and 3 (L2&3), layer 3c (L3c) and layer 5 (L5) of the human cortex. Across all layers we observe notable heterogeneity, indicating human cortical pyramidal neurons are an electrophysiologically diverse population. L5 pyramidal cells are the most excitable of these neurons and exhibit the most prominent sag current (abolished by blockade of the hyperpolarization activated cation current, Ih). While subthreshold resonance is more common in L3c and L5, we rarely observe this resonance at frequencies greater than 2 Hz. However, the frequency dependent gain of L5 neurons reveals they are most adept at tracking both delta and theta frequency inputs, a unique feature that may indirectly be important for the generation of cortical theta oscillations.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22741-9

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DOI: 10.1038/s41467-021-22741-9

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